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Cefuroxime (Ceftin) for Acute Otitis Media
ceftinCefuroxime (Ceftin) is not considered a drug of first choice for initial treatment of otitis media. Cefuroxime (Ceftin) is recommended as an alternative to amoxicillin or amoxicillin/clavulanate potassium when these drugs are ineffective or cannot be used (e.g., in persons with a history hypersensitivity reactions to penicillins).

Results of clinical studies in children 3 months to 12 years of age with acute otitis media show that a 10-day regimen of Cefuroxime (Ceftin) axetil is as effective or more effective than a 10-day regimen of cefaclor, amoxicillin, or amoxicillin/clavulanate potassium3. According to the studies, the overall symptoms improvement rate to a 10-day course of oral Cefuroxime (Ceftin) axetil in children with otitis media ranges from 62–94%.

Cefuroxime (Ceftin) axetil is used for the treatment of acute otitis media caused by S. pneumoniae, H. influenzae (including beta-lactamase-producing strains), M. catarrhalis (including beta-lactamase-producing strains), or S. pyogenes.

Cefuroxime (Ceftin) for Pharyngitis and Tonsillitis (Strep Throat)

Cefuroxime (Ceftin) is used for the treatment of pharyngitis and tonsillitis caused by S. pyogenes (group A beta-hemolytic streptococci).

A 10-day regimen of Cefuroxime (Ceftin) is at least as effective as a 10-day regimen of penicillin V for the treatment of streptococcal pharyngitis and tonsillitis4. In addition, results of a prospective, randomized study in children 2–15 years of age indicate that a 4-day regimen of Cefuroxime (Ceftin) axetil (20 mg/kg of Cefuroxime (Ceftin) in 2 divided doses daily) is as effective as a 10-day regimen of penicillin V (45 mg/kg daily in 3 divided doses). The symptoms improvement rate was 94.8% in those who received the 4-day Cefuroxime (Ceftin) and 96.1% in those who received the 10-day penicillin. 30 days after treatment, the infection relapse rate was 2.8 and 2.3%, respectively.

Cefuroxime (Ceftin) for Respiratory Tract Infections
Cefuroxime (Ceftin) axetil is used orally for the treatment of mild to moderate respiratory tract infections, including acute maxillary sinusitis and acute exacerbations of chronic bronchitis and secondary infections of acute bronchitis.

Cefuroxime (Ceftin) sodium is used parenterally for the treatment of lower respiratory tract infections, including pneumonia, caused by susceptible S. pneumoniae, Staphylococcus aureus (penicillinase- and nonpenicillinase-producing strains), S. pyogenes (group A beta-hemolytic streptococci), H. influenzae (including ampicillin-resistant strains), Escherichia coli, and Klebsiella.

Gonorrhea
 
Cefuroxime (Ceftin) is used orally for the treatment of uncomplicated urethral and endocervical gonorrhea and for the treatment of uncomplicated rectal gonorrhea in women. However, Cefuroxime (Ceftin) is not considered a preferred medication for the treatment of gonococcal infections.

In a study comparing efficacy of a single 1g oral dose of Cefuroxime (Ceftin) or a single 500mg oral dose of ciprofloxacin in adults with uncomplicated gonorrhea, both regimens appeared to be equally effective in eradicating urethral, endocervical, and rectal infections in women (eradication rate: 97–99%). However, the eradication rate in men with uncomplicated urethral infections was 93% in those who received Cefuroxime (Ceftin) axetil and 100% in those who received ciprofloxacin. While only a limited number of patients in the study had pharyngeal gonococcal infections, the single-dose oral Cefuroxime (Ceftin) axetil regimen appeared to be slightly less effective than the single-dose oral ciprofloxacin. In a study in women with uncomplicated gonorrhea who received a single 1g oral dose of Cefuroxime (Ceftin), the cure rate ranged from 96–99% in those with urethral, endocervical, or rectal infections; in those with pharyngeal gonorrhea, the cure rate with Cefuroxime (Ceftin) was 60%.

Early Lyme Disease
Cefuroxime (Ceftin) axetil is used for the treatment of early Lyme disease manifested as erythema migrans. The Infectious Diseases Society of America (IDSA), American Academy of Pediatrics (AAP), and other clinicians recommend oral doxycycline, oral amoxicillin, or oral Cefuroxime (Ceftin) axetil as first-line therapy for the treatment of early Lyme disease associated with erythema migrans, in the absence of specific neurologic involvement or advanced atrioventricular (AV) heart block.

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